TEMPORAL REQUIREMENTS OF THE FRAGILE X MENTAL RETARDATION PROTEIN IN MODULATING CIRCADIAN CLOCK CIRCUIT SYNAPTIC ARCHITECTURE

Temporal requirements of the fragile X mental retardation protein in modulating circadian clock circuit synaptic architecture

Loss of fragile X mental retardation 1 (FMR1) gene function is the most common cause of inherited mental retardation and autism spectrum disorders, characterized by attention disorder, hyperactivity and disruption of Puzzle Necklace circadian activity cycles.Pursuit of effective intervention strategies requires determining when the FMR1 product (FM

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